Our research group aims to design and develop novel clinically relevant antimicrobial wound matrices. In parallel with the development of wound matrices we also develop methods and models which enable to understand the safety and structure and activity relationships of electrospun fibrous matrices, and more importantly understand the wound matrix- bacteria- eukaryotic cell interactions in biorelevant wound environment. Now in addition to the antimicrobial drugs we have started to incorporate living bacterial cells capable to produce antimicrobial substances into the electrospun nanofibers. Such electrospun wound matrices can be tuned to be sensitive and responsive to the environmental changes in the wound.
We are seeking for new and promising strategies that allow antibacterial/antimicrobial therapies and patients’ quality of life to be improved.